This review article summarizes important experimental evidence involving some TRP ion channels as molecular sensors of chemical, thermal, and mechanical noxious stimuli to evoke the pain and itch sensations.

This manuscript describes how TRPblue’s lead compound (TB16-8) was discovered by increasing the TRPV4 potency of a known tool compound which resulted in the ability for this novel compound to inhibit TRPA1 as well.  This novel dual-channel blocker inhibited inflammation and pain-associated behavior in a model of acute pancreatitis – known to also rely on TRPV4 and TRPA1.

This article is one of the first to describe the role of TRPA1 and TRPV4 as key pathways in chemotherapy induced peripheral neuropathy in an animal model.