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Small Molecule Dual-Inhibitors of TRPV4 and TRPA1 for Attenuation of Inflammation and Pain

By June 1, 2016November 24th, 2020No Comments

This manuscript describes how TRPblue’s lead compound (TB16-8) was discovered by increasing the TRPV4 potency of a known tool compound which resulted in the ability for this novel compound to inhibit TRPA1 as well.  This novel dual-channel blocker inhibited inflammation and pain-associated behavior in a model of acute pancreatitis – known to also rely on TRPV4 and TRPA1.